Skin graft associated with platelet-rich plasma in correcting extensive injuries resulting from the resection of skin cancer chemically induced in rats.

PURPOSE: To evaluate whether using platelet-rich plasma (PRP) in the graft recipient bed after the resection of a neoplasia can influence its recurrence because this product stimulates angiogenesis, mitogenesis and chemotaxis. METHODS: A study with 30 rats Wistar (Rattus norvegicus albinus), which were separated into group A (induction of carcinogenesis, PRP in the postoperative period) and group B (induction of carcinogenesis, absence of PRP in the postoperative period), with 15 animals in each. Carcinogenesis was induced on the skin of the animals' chest by the topical application of 0.5% dimethylbenzantracene (DMBA) diluted in acetone. After surgical resection of the induced neoplasia, PRP was used to stimulate angiogenesis before surgical wound synthesis. Data on the control and experimental groups and macroscopic and microscopic variables were evaluated using analysis of variance and the Tukey's test (5%). RESULTS: It was possible to determine that the use of PRP is good in reconstructive surgeries, but it is contraindicated in patients during tumor resection, as it can cause changes in the surgical bed, in addition to stimulating recurrences and metastases. CONCLUSIONS: PRP may interact with tumour cells that were in the recipient site of the surgical wound during the resection of a neoplasia, and a local recurrence process can be triggered by applying this product.

Skin graft associated with platelet-rich plasma in correcting extensive injuries resulting from the resection of skin cancer chemically induced in rats

ABSTRACT Purpose: To evaluate whether using platelet-rich plasma (PRP) in the graft recipient bed after the resection of a neoplasia can influence its recurrence because this product stimulates angiogenesis, mitogenesis and chemotaxis. Methods: A study with 30 rats Wistar (Rattus norvegicus albinus), which were separated into group A (induction of carcinogenesis, PRP in the postoperative period) and group B (induction of carcinogenesis, absence of PRP in the postoperative period), with 15 animals in each. Carcinogenesis was induced on the skin of the animals' chest by the topical application of 0.5% dimethylbenzantracene (DMBA) diluted in acetone. After surgical resection of the induced neoplasia, PRP was used to stimulate angiogenesis before surgical wound synthesis. Data on the control and experimental groups and macroscopic and microscopic variables were evaluated using analysis of variance and the Tukey's test (5%). Results: It was possible to determine that the use of PRP is good in reconstructive surgeries, but it is contraindicated in patients during tumor resection, as it can cause changes in the surgical bed, in addition to stimulating recurrences and metastases. Conclusions: PRP may interact with tumour cells that were in the recipient site of the surgical wound during the resection of a neoplasia, and a local recurrence process can be triggered by applying this product.

Ten-year seasonal climate reforecasts over South America using the Eta Regional Climate Model.

Ten-year seasonal climate reforecasts over South America are obtained using the Eta Regional Climate Model at 40 km resolution, driven by the large-scale forcing from the global atmospheric model of the Center for Weather Forecasts and Climate Studies. The objective of this work is to evaluate these regional reforecasts. The dataset is comprised of four-month seasonal forecasts performed on a monthly basis between 2001 and 2010. An ensemble of five members is constructed from five slightly different initial conditions to partially reduce the uncertainty in the seasonal forecasts. The seasonal mean precipitation and 2-meter temperature forecasts are compared with the observations. The comparison shows that, in general, forecasted precipitation is underestimated in the central part of the continent in the austral summer, whereas the forecasted 2 meter temperature is underestimated in most parts of the continent and throughout the year. Skill scores show higher skill in the northern part of the continent and lower skill in the southern part of the continent, but mixed skill signs are seen in the central part of the continent. During the El Niño and La Niña seasons, the forecast skill scores clearly increase. The downscaling of the Eta model seasonal forecasts provides added value over the driver global model forecasts, especially during rainy periods.

Effect of Volume in Resistance Training on Inhibitory Control in Young Adults: A Randomized and Crossover Investigation.

Purpose: The aim of the study is to compare the effect of resistance training volume on inhibitory control in young adults with previous experience in resistance training. Method: All the 27 participants underwent 40-week experiment, divided in three training phases of 8-week duration. A washout period of 8 weeks between each of the training phases was carried out. The participants performed 1, 3, or 5 sets of the same exercises with equalized intensity (loading zones) and rest. Inhibitory control was assessed by the Stroop Test. Results: Interaction effect was found for inhibitory control accuracy [F (5,22) = 56.88, p < 0.01] and mean response time [F (5,22) = 83.02, p < 0.01] for 3 sets (p = 0.01; ES = 0.6) and 5 sets (p = 0.01; ES = 0.8) when compared to 1 set. Conclusion: In conclusion, 1 set of resistance training may provide insufficient volume stimulus for positive adaptation in inhibitory control when compared to 3 or 5 sets.